Oligo-therapy, the use of trace elements normally found in the human body that act as catalysts in maintaining proper physiological functions. Oligo-therapy or trace element also called biocatalyst, is a method of furnishing the body with the ions that the organism cannot synthesize on its own and which are indispensable for cellular enzymatic functions. These biocatalysts must be provided in an ionized form and in ppm or less, so that they can be immediately transported and utilized in the body. Trace elements are just as indispensable as vitamins. Although the requirements of an average 70 kg person can adequately be filled by a daily intake of 60 mg of trace elements, shortage of one single trace element can lead to very serious problems, chronic deficiency and malaise and fatigue. Trace elements are metals or metalloids contained in the human body in very small amounts which are indispensable to effective organic functioning. Trace elements are mineral particles that occur in minute quantity in all living plant and animal organisms. 30 of these trace elements such as manganese, cobalt, selenium, zinc, iodine, iron, copper, fluorine, chrome, nickel, silver, gold have been researched and their functions are known. Trace elements are also known as Oligo-elements, which comes from the Greek work OLIGOS meaning very small, because it is the very small ionic fraction that is taken into consideration and not the corresponding weight in mineral salt. It is essential to emphasize the distinction between catalytic Oligo-therapy intended to improve diathesis by catalysis on one hand and supplying a certain weight on mineral salts on the other, which corresponds to an entirely different application and another plan of action. The active doses of trace elements are not extremely heavy, nor infinitesimal as in homeopathy but are found at an intermediate level that corresponds to the energetic or electromagnetic level of the living being. A trace element does not work by means of an effect of mass but as an informing element. Trace elements are catalysts that play a part in the functions of the organism by permitting its permanent adaptation to the environment. Trace elements are major modifiers of diathesis. Minerals are macro-elements as opposed to trace elements that are microelements. If we compare trace element intake, the required intake of minerals is 157-fold and it should be borne in mind that trace element deficiencies are very common. Macro means more than 100mg per day such calcium, phosphorus, chlorine, magnesium, sodium, sulphur, and potassium. Trace usually means we do not know how much we need and it is a very small quantity such cobalt, chromium, iodine, iron, copper, fluorine, manganese, molybdenum, nickel, selenium, silicon, tin, vanadium, zinc. Universal agreement that all trace elements are essential for human body. Although several diseases have been linked with deficiencies of certain elements but deficiency amounts have never been determined for most trace elements.