The endocannabinoid system (ECS) is a complex signaling network involved in several physiological processes, including pain perception, mood regulation, and immune function. Natural therapies, such as herbal medicine and phytotherapy, have been shown to interact with the ECS and modulate its activity. This research project aims to investigate the interactions between the ECS and natural therapies, including medicinal plants such as cannabis, echinacea, and black pepper. The study will involve a comprehensive literature review and in vitro and in vivo studies to evaluate the effects of natural compounds on the ECS and their potential therapeutic applications. The findings of this research could provide new insights into the development of natural-based therapies that target the ECS and promote health and wellness.